Helper (CD4+) and cytotoxic (CD8+) T cells promote the pathology of dystrophin-deficient muscle
MJ Spencer, E Montecino-Rodriguez, K Dorshkind… - Clinical …, 2001 - Elsevier
Duchenne muscular dystrophy (DMD) and mdx mouse dystrophy result from mutations in the
dystrophin gene. Although these mutations are primarily responsible for the defects that
underlie the pathology of dystrophinopathies, other factors may contribute importantly to the
pathology. In the present investigation, we tested whether T cells present in mdx muscles
are activated and contribute significantly to the pathological process. Flow cytometric
analyses showed a significantly higher frequency of activated CD44high T cells in the blood …
dystrophin gene. Although these mutations are primarily responsible for the defects that
underlie the pathology of dystrophinopathies, other factors may contribute importantly to the
pathology. In the present investigation, we tested whether T cells present in mdx muscles
are activated and contribute significantly to the pathological process. Flow cytometric
analyses showed a significantly higher frequency of activated CD44high T cells in the blood …
