Heat shock protein 27 controls apoptosis by regulating Akt activation
MJ Rane, Y Pan, S Singh, DW Powell, R Wu… - Journal of Biological …, 2003 - ASBMB
Activation of the serine-threonine kinase Akt by cytokines, chemokines, and bacterial
products delays constitutive neutrophil apoptosis, resulting in a prolonged inflammatory
response. We showed previously that Akt exists in a signaling complex with p38 MAPK,
MAPK-activated protein kinase-2 (MAPKAPK-2), and heat shock protein-27 (Hsp27); and
Hsp27 dissociates from the complex upon neutrophil activation. To better understand the
regulation of this signaling module, the hypothesis that Akt phosphorylation of Hsp27 …
products delays constitutive neutrophil apoptosis, resulting in a prolonged inflammatory
response. We showed previously that Akt exists in a signaling complex with p38 MAPK,
MAPK-activated protein kinase-2 (MAPKAPK-2), and heat shock protein-27 (Hsp27); and
Hsp27 dissociates from the complex upon neutrophil activation. To better understand the
regulation of this signaling module, the hypothesis that Akt phosphorylation of Hsp27 …
