[HTML][HTML] VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function
E Tzima, JS Reader, M Irani-Tehrani, KL Ewalt… - Journal of Biological …, 2005 - ASBMB
A natural fragment of an enzyme that catalyzes the first step of protein synthesis—human
tryptophanyl-tRNA synthetase (T2-TrpRS) has potent anti-angiogenic activity. A cellular
receptor through which T2-TrpRS exerts its anti-angiogenic activity has not previously been
identified. Here T2-TrpRS was shown to bind at intercellular junctions of endothelial cells
(ECs). Using genetic knock-outs, binding was established to depend on VE-cadherin, a
calcium-dependent adhesion molecule, which is selectively expressed in ECs, concentrated …
tryptophanyl-tRNA synthetase (T2-TrpRS) has potent anti-angiogenic activity. A cellular
receptor through which T2-TrpRS exerts its anti-angiogenic activity has not previously been
identified. Here T2-TrpRS was shown to bind at intercellular junctions of endothelial cells
(ECs). Using genetic knock-outs, binding was established to depend on VE-cadherin, a
calcium-dependent adhesion molecule, which is selectively expressed in ECs, concentrated …
