[HTML][HTML] The PDZ-interacting domain of cystic fibrosis transmembrane conductance regulator is required for functional expression in the apical plasma membrane
Polarization of cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-
activated chloride channel to the apical plasma membrane in epithelial cells is critical for
vectorial chloride transport. Previously, we reported that the C terminus of CFTR constitutes
a PDZ-interacting domain that is required for CFTR polarization to the apical plasma
membrane and interaction with the PDZ domain-containing protein EBP50 (NHERF). PDZ-
interacting domains are typically composed of the C-terminal three to five amino acids …
activated chloride channel to the apical plasma membrane in epithelial cells is critical for
vectorial chloride transport. Previously, we reported that the C terminus of CFTR constitutes
a PDZ-interacting domain that is required for CFTR polarization to the apical plasma
membrane and interaction with the PDZ domain-containing protein EBP50 (NHERF). PDZ-
interacting domains are typically composed of the C-terminal three to five amino acids …
