Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na+/H+ exchanger regulatory factor 1 (NHERF1) null mice: cAMP inhibition is differentially …
R Murtazina, O Kovbasnjuk, NC Zachos, X Li… - Journal of Biological …, 2007 - ASBMB
The multi-PDZ domain containing protein Na+/H+ Exchanger Regulatory Factor 1 (NHERF1)
binds to Na+/H+ exchanger 3 (NHE3) and is associated with the brush border (BB)
membrane of murine kidney and small intestine. Although studies in BB isolated from kidney
cortex of wild type and NHERF1-/-mice have shown that NHERF1 is necessary for cAMP
inhibition of NHE3 activity, a role of NHERF1 in NHE3 regulation in small intestine and in
intact kidney has not been established. Here a method using multi-photon microscopy with …
binds to Na+/H+ exchanger 3 (NHE3) and is associated with the brush border (BB)
membrane of murine kidney and small intestine. Although studies in BB isolated from kidney
cortex of wild type and NHERF1-/-mice have shown that NHERF1 is necessary for cAMP
inhibition of NHE3 activity, a role of NHERF1 in NHE3 regulation in small intestine and in
intact kidney has not been established. Here a method using multi-photon microscopy with …
