Balance in asthma between matrix metalloproteinases and their inhibitors
G Mautino, F Capony, J Bousquet… - Journal of allergy and …, 1999 - jacionline.org
Mautino et al 531 smooth muscle, vascular remodeling, collagen deposition below the
basement membrane, and elastolysis. Is remodeling of the airways a proved clinical
concept? 4 It is clear that changes in the ECM and bronchial wall structure have the capacity
to influence airway function in asthma. However, it is not known how each of the many
changes that occur in the airway wall contribute to permanently altered airway function in
some asthmatic patients. There are other clinical consequences of remodeling. The increase …
basement membrane, and elastolysis. Is remodeling of the airways a proved clinical
concept? 4 It is clear that changes in the ECM and bronchial wall structure have the capacity
to influence airway function in asthma. However, it is not known how each of the many
changes that occur in the airway wall contribute to permanently altered airway function in
some asthmatic patients. There are other clinical consequences of remodeling. The increase …