Atmospheric oxygen accelerates the induction of a post-mitotic phenotype in human dermal fibroblasts: the key protective role of glutathione
S Alaluf, H Muir-Howie, HL Hu, A Evans, MR Green - Differentiation, 2000 - Elsevier
It has been proposed that ageing of human dermal fibroblasts occurs as a multi-stage
process during which cells progress from a mitotic to a post-mitotic state. We describe the
development of a simple and novel cell-cloning model for identifying and quantifying the
different fibroblast morphotypes associated with the induction of post mitotic behaviour. We
have found that under atmospheric (20%) oxygen tension a significant proportion of human
dermal fibroblasts are rapidly induced to switch from a mitotic to a post-mitotic phenotype. In …
process during which cells progress from a mitotic to a post-mitotic state. We describe the
development of a simple and novel cell-cloning model for identifying and quantifying the
different fibroblast morphotypes associated with the induction of post mitotic behaviour. We
have found that under atmospheric (20%) oxygen tension a significant proportion of human
dermal fibroblasts are rapidly induced to switch from a mitotic to a post-mitotic phenotype. In …
