[HTML][HTML] Alcohol/cholecystokinin-evoked pancreatic acinar basolateral exocytosis is mediated by protein kinase Cα phosphorylation of Munc18c
LI Cosen-Binker, PPL Lam, MG Binker, J Reeve… - Journal of biological …, 2007 - ASBMB
The pancreatic acinus is the functional unit of the exocrine pancreas whose role is to secrete
zymogens into the gut lumen for food digestion via apical exocytosis. We previously reported
that supramaximal CCK induced apical blockade and redirected exocytosis to ectopic sites
on the basolateral plasma membrane (BPM) of this polarized cell, leading to pancreatitis.
Basolateral exocytosis was mediated by protein kinase C phosphorylation of BPM Munc18c,
causing its displacement into the cytosol and activation of BPM-bound Syntaxin-4 to form a …
zymogens into the gut lumen for food digestion via apical exocytosis. We previously reported
that supramaximal CCK induced apical blockade and redirected exocytosis to ectopic sites
on the basolateral plasma membrane (BPM) of this polarized cell, leading to pancreatitis.
Basolateral exocytosis was mediated by protein kinase C phosphorylation of BPM Munc18c,
causing its displacement into the cytosol and activation of BPM-bound Syntaxin-4 to form a …