[HTML][HTML] Simian Virus 40 T Antigen-induced Amplification of Pre-parietal Cells in Transgenic Mice.: EFFECTS ON OTHER GASTRIC EPITHELIAL CELL LINEAGES …

Q Li, SM Karam, JI Gordon - Journal of Biological Chemistry, 1995 - ASBMB
Gastric units in the glandular epithelium of the mouse stomach contain several types of
continuously renewing epithelial cells. Acid-producing parietal cells are derived from a
multipotent stem cell that also gives rise to mucus-producing pit cells and pepsinogen-and
intrinsic factor-producing zymogenic cells. We used nucleotides− 1035 to+ 24 of the mouse
H+/K+-ATPase β subunit gene (H+/K+-ATPase β subunit⁻ 1035 to⁺ 24) to examine the
consequences of expressing simian virus 40 T antigen (SV40 TAg) in the normally rare …