[HTML][HTML] Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase
BJ Michell, Z Chen, T Tiganis, D Stapleton… - Journal of biological …, 2001 - ASBMB
Endothelial nitric-oxide synthase (eNOS) is an important regulatory enzyme in the
cardiovascular system catalyzing the production of NO from arginine. Multiple protein
kinases including Akt/PKB, cAMP-dependent protein kinase (PKA), and the AMP-activated
protein kinase (AMPK) activate eNOS by phosphorylating Ser-1177 in response to various
stimuli. During VEGF signaling in endothelial cells, there is a transient increase in Ser-1177
phosphorylation coupled with a decrease in Thr-495 phosphorylation that reverses over 10 …
cardiovascular system catalyzing the production of NO from arginine. Multiple protein
kinases including Akt/PKB, cAMP-dependent protein kinase (PKA), and the AMP-activated
protein kinase (AMPK) activate eNOS by phosphorylating Ser-1177 in response to various
stimuli. During VEGF signaling in endothelial cells, there is a transient increase in Ser-1177
phosphorylation coupled with a decrease in Thr-495 phosphorylation that reverses over 10 …