Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys
C Sagrinati, GS Netti, B Mazzinghi… - Journal of the …, 2006 - journals.lww.com
Regenerative medicine represents a critical clinical goal for patients with ESRD, but the
identification of renal adult multipotent progenitor cells has remained elusive. It is
demonstrated that in human adult kidneys, a subset of parietal epithelial cells (PEC) in the
Bowman's capsule exhibit coexpression of the stem cell markers CD24 and CD133 and of
the stem cell–specific transcription factors Oct-4 and BmI-1, in the absence of lineage-
specific markers. This CD24+ CD133+ PEC population, which could be purified from …
identification of renal adult multipotent progenitor cells has remained elusive. It is
demonstrated that in human adult kidneys, a subset of parietal epithelial cells (PEC) in the
Bowman's capsule exhibit coexpression of the stem cell markers CD24 and CD133 and of
the stem cell–specific transcription factors Oct-4 and BmI-1, in the absence of lineage-
specific markers. This CD24+ CD133+ PEC population, which could be purified from …
