Radiotherapy adapted to spatial and temporal variability in tumor hypoxia
Å Søvik, E Malinen, HK Skogmo, SM Bentzen… - International Journal of …, 2007 - Elsevier
Purpose: To explore the feasibility and clinical potential of adapting radiotherapy to temporal
and spatial variations in tumor oxygenation. Methods and Materials: Repeated dynamic
contrast enhanced magnetic resonance (DCEMR) images were taken of a canine sarcoma
during the course of fractionated radiation therapy. The tumor contrast enhancement was
assumed to represent the oxygen distribution. The IMRT plans were retrospectively adapted
to the DCEMR images by employing tumor dose redistribution. Optimized nonuniform tumor …
and spatial variations in tumor oxygenation. Methods and Materials: Repeated dynamic
contrast enhanced magnetic resonance (DCEMR) images were taken of a canine sarcoma
during the course of fractionated radiation therapy. The tumor contrast enhancement was
assumed to represent the oxygen distribution. The IMRT plans were retrospectively adapted
to the DCEMR images by employing tumor dose redistribution. Optimized nonuniform tumor …