Experimental evidence suggests that the hypoxic fraction in a solid tumor may increase its
malignant potential and reduce its sensitivity towards non-surgical treatment modalities (eg
standard irradiation, certain anticancer agents). However, the clinical importance of tumor
hypoxia remains uncertain since valid methods for the routine measurement of intratumoral
O 2-tensions in patients have so far been lacking. A clinically applicable standardized
procedure has been established which enables the determination of intratumoral oxygen …