[HTML][HTML] The photoreceptor rim protein is an ABC transporter encoded by the gene for recessive Stargardt's disease (ABCR)
SM Azarian, GH Travis - FEBS letters, 1997 - Elsevier
SM Azarian, GH Travis
FEBS letters, 1997•ElsevierRim protein (RmP) is a high-Mr membrane glycoprotein that has been localized to the rims
of photoreceptor outer segment discs, but its molecular identity is unknown. Here, we
describe the purification of RmP and present the sequence of its mRNA. RmP is a new
member of the ATP-binding cassette (ABC) transporter superfamily. We show that RmP is
expressed specifically in photoreceptors and predominantly in outer segments. Further,
RmP is identical to the protein recently shown to be affected in recessive Stargardt's …
of photoreceptor outer segment discs, but its molecular identity is unknown. Here, we
describe the purification of RmP and present the sequence of its mRNA. RmP is a new
member of the ATP-binding cassette (ABC) transporter superfamily. We show that RmP is
expressed specifically in photoreceptors and predominantly in outer segments. Further,
RmP is identical to the protein recently shown to be affected in recessive Stargardt's …
Rim protein (RmP) is a high-Mr membrane glycoprotein that has been localized to the rims of photoreceptor outer segment discs, but its molecular identity is unknown. Here, we describe the purification of RmP and present the sequence of its mRNA. RmP is a new member of the ATP-binding cassette (ABC) transporter superfamily. We show that RmP is expressed specifically in photoreceptors and predominantly in outer segments. Further, RmP is identical to the protein recently shown to be affected in recessive Stargardt's disease. RmP is the first ABC transporter observed in photoreceptors and may play a role in the photoresponse.
Elsevier