Analysis of cystic fibrosis gener product (CFTR) function in patients with pancreas divisum and recurrent acute pancreatitis
A Gelrud, S Sheth, S Banerjee, D Weed… - Official journal of the …, 2004 - journals.lww.com
A Gelrud, S Sheth, S Banerjee, D Weed, J Shea, R Chuttani, DA Howell, JJ Telford…
Official journal of the American College of Gastroenterology| ACG, 2004•journals.lww.comBACKGROUND The mechanism by which pancreas divisum may lead to recurrent episodes
of acute pancreatitis in a subset of individuals is unknown. Abnormalities of the cystic fibrosis
gene product (CFTR) have been implicated in the genesis of idiopathic chronic pancreatitis.
The aim of this study was to determine if CFTR function is abnormal in patients with
pancreas divisum and recurrent acute pancreatitis (PD/RAP). METHODS A total of 69
healthy control subjects, 12 patients with PD/RAP, 16 obligate heterozygotes with a single …
of acute pancreatitis in a subset of individuals is unknown. Abnormalities of the cystic fibrosis
gene product (CFTR) have been implicated in the genesis of idiopathic chronic pancreatitis.
The aim of this study was to determine if CFTR function is abnormal in patients with
pancreas divisum and recurrent acute pancreatitis (PD/RAP). METHODS A total of 69
healthy control subjects, 12 patients with PD/RAP, 16 obligate heterozygotes with a single …
Abstract
BACKGROUND
The mechanism by which pancreas divisum may lead to recurrent episodes of acute pancreatitis in a subset of individuals is unknown. Abnormalities of the cystic fibrosis gene product (CFTR) have been implicated in the genesis of idiopathic chronic pancreatitis. The aim of this study was to determine if CFTR function is abnormal in patients with pancreas divisum and recurrent acute pancreatitis (PD/RAP).
METHODS
A total of 69 healthy control subjects, 12 patients with PD/RAP, 16 obligate heterozygotes with a single CFTR mutation, and 95 patients with cystic fibrosis were enrolled. CFTR function was analyzed by nasal transepithelial potential difference testing in vivo. The outcomes of the PD/RAP patients following endoscopic and surgical treatments were concomitantly analyzed.
Lippincott Williams & Wilkins