Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates.
PH Wooley, HS Luthra, JM Stuart… - The Journal of …, 1981 - rupress.org
PH Wooley, HS Luthra, JM Stuart, CS David
The Journal of experimental medicine, 1981•rupress.orgA model of arthritis was established by the injection of type II collagen into mice. Only mice
bearing the H-2q haplotype were susceptible to the disease. Susceptibility was further
mapped by the use of recombinant strains on the Iq locus. Type II collagen arthritis was
observed in the (resistant X susceptible) F1 cross. Mice strains were designated high,
intermediate, or low responders with respect to the anti-type II antibody levels measured by
radioimmunoassay. Arthritis-susceptible strains were all classified as high antibody …
bearing the H-2q haplotype were susceptible to the disease. Susceptibility was further
mapped by the use of recombinant strains on the Iq locus. Type II collagen arthritis was
observed in the (resistant X susceptible) F1 cross. Mice strains were designated high,
intermediate, or low responders with respect to the anti-type II antibody levels measured by
radioimmunoassay. Arthritis-susceptible strains were all classified as high antibody …
A model of arthritis was established by the injection of type II collagen into mice. Only mice bearing the H-2q haplotype were susceptible to the disease. Susceptibility was further mapped by the use of recombinant strains on the Iq locus. Type II collagen arthritis was observed in the (resistant X susceptible) F1 cross. Mice strains were designated high, intermediate, or low responders with respect to the anti-type II antibody levels measured by radioimmunoassay. Arthritis-susceptible strains were all classified as high antibody responders. The clinical and histological appearance of type II collagen arthritis in the mouse indicates that it may be a good animal model for the investigation of various immunogenetic traits in rheumatoid arthritis.
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