The rheumatoid arthritis specific Sa antigen is citrullinated vimentin
ER Vossenaar, N Deprés, M Lora, A van der Heijden… - Arthritis Res Ther, 2004 - Springer
ER Vossenaar, N Deprés, M Lora, A van der Heijden, E Lapointe, AJW Zendman, T Senshu…
Arthritis Res Ther, 2004•SpringerBackground Antibodies directed at the Sa antigen are highly specific for rheumatoid arthritis
(RA) and can be detected in approximately 40% of RA sera. The antigen, a doublet of
protein bands of about 50 kDa, is present in placenta and in RA synovial tissue. Although it
has been suggested that the Sa antigen is identical to citrullinated vimentin, experimental
proof for this has never been published. Objective
(RA) and can be detected in approximately 40% of RA sera. The antigen, a doublet of
protein bands of about 50 kDa, is present in placenta and in RA synovial tissue. Although it
has been suggested that the Sa antigen is identical to citrullinated vimentin, experimental
proof for this has never been published. Objective
Background
Antibodies directed at the Sa antigen are highly specific for rheumatoid arthritis (RA) and can be detected in approximately 40% of RA sera. The antigen, a doublet of protein bands of about 50 kDa, is present in placenta and in RA synovial tissue. Although it has been suggested that the Sa antigen is identical to citrullinated vimentin, experimental proof for this has never been published.
Objective
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