Drusen are subretinal pigment epithelial deposits that are characteristic of but not uniquely
associated with age-related macular degeneration (AMD). Age-related macular
degeneration is associated with two types of drusen that have different clinical appearances
and different prognoses. Hard drusen appear as small, punctate, yellow nodules and can
precede the development of atrophic AMD. Areolar atrophy of the retinal pigment epithelium
(RPE), choriocapillaris, and outer retina develop as the drusen disappear, but drusen can …