Microarray Analysis and Functional Characterization of the Nitrosative Stress Response in Nonmucoid and Mucoid Pseudomonas aeruginosa

AM Firoved, SR Wood, W Ornatowski… - Journal of …, 2004 - Am Soc Microbiol
AM Firoved, SR Wood, W Ornatowski, V Deretic, GS Timmins
Journal of bacteriology, 2004Am Soc Microbiol
The type strain of Pseudomonas aeruginosa, PAO1, showed great upregulation of many
nitrosative defense genes upon treatment with S-nitrosoglutathione, while the mucoid strain
PAO578II showed no further upregulation above its constitutive upregulation of nor and fhp.
NO· consumption however, showed that both strains mount functional, protein synthesis-
dependent NO·-consumptive responses.
Abstract
The type strain of Pseudomonas aeruginosa, PAO1, showed great upregulation of many nitrosative defense genes upon treatment with S-nitrosoglutathione, while the mucoid strain PAO578II showed no further upregulation above its constitutive upregulation of nor and fhp. NO· consumption however, showed that both strains mount functional, protein synthesis-dependent NO·-consumptive responses.
American Society for Microbiology