[HTML][HTML] Mechanism of Digeranylgeranylation of Rab Proteins: FORMATION OF A COMPLEX BETWEEN MONOGERANYLGERANYL-Rab AND Rab ESCORT …

F Shen, MC Seabra - Journal of Biological Chemistry, 1996 - ASBMB
Rab proteins are Ras-related small GTPases that are digeranylgeranylated at carboxyl-
terminal cysteines, a modification essential for their action as molecular switches regulating
intracellular vesicular transport. Geranylgeranylation of Rabs is a complex reaction that
requires a catalytic Rab geranylgeranyl transferase (GGTase) and a Rab escort protein
(REP). REP binds unprenylated Rab and presents it to Rab GGTase. After GG transfer, REP
remains associated with diGG-Rab, which leads to insertion of the Rab into a specific …