Sensitization of rat sensory neurons by chronic exposure to forskolin or 'inflammatory cocktail'does not downregulate and requires continuous exposure
LA Bolyard, JW Van Looy, MR Vasko - Pain, 2000 - Elsevier
Sensitization of sensory neurons is a critical component of hypersensitivity that occurs
during chronic pain and inflammation. Questions remain, however, whether this sensitization
depends on the continuous activation of signal transduction pathways in sensory neurons,
whether the sensitization persists once the agent causing sensitization is removed, and
whether downregulation occurs in the ability of these neurons to be sensitized. Because
activation of the cAMP transduction cascade produces acute sensitization in rat sensory …
during chronic pain and inflammation. Questions remain, however, whether this sensitization
depends on the continuous activation of signal transduction pathways in sensory neurons,
whether the sensitization persists once the agent causing sensitization is removed, and
whether downregulation occurs in the ability of these neurons to be sensitized. Because
activation of the cAMP transduction cascade produces acute sensitization in rat sensory …
