Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor
KL Widdowson, JD Elliott, DF Veber, H Nie… - Journal of medicinal …, 2004 - ACS Publications
KL Widdowson, JD Elliott, DF Veber, H Nie, MC Rutledge, BW McCleland, JN Xiang…
Journal of medicinal chemistry, 2004•ACS PublicationsN, N '-Diarylureas were prepared, and the structure− activity relationship relative to the
CXCR2 receptor was examined. This led to the identification of a potent and highly selective
CXCR2 antagonist, which in addition was shown to be functionally active both in vitro
against human neutrophils and in vivo in rabbit models of ear edema and neutropenia.
CXCR2 receptor was examined. This led to the identification of a potent and highly selective
CXCR2 antagonist, which in addition was shown to be functionally active both in vitro
against human neutrophils and in vivo in rabbit models of ear edema and neutropenia.
N,N‘-Diarylureas were prepared, and the structure−activity relationship relative to the CXCR2 receptor was examined. This led to the identification of a potent and highly selective CXCR2 antagonist, which in addition was shown to be functionally active both in vitro against human neutrophils and in vivo in rabbit models of ear edema and neutropenia.
ACS Publications