[HTML][HTML] Chemokine antagonists that discriminate between interleukin-8 receptors: selective blockers of CXCR2
SA Jones, B Dewald, I Clark-Lewis… - Journal of Biological …, 1997 - ASBMB
Human neutrophils express two interleukin (IL)-8 receptors, CXC chemokine receptor
(CXCR) 1 and CXCR2. IL-8 with changes to the NH 2-terminal ELR motif can block IL-8-
induced neutrophil functions (Moser, B., Dewald, B., Barella, L., Schumacher, C., Baggiolini,
M., and Clark-Lewis, I.(1993) J. Biol. Chem. 268, 7125–7128). We have now examined the
effect of NH 2-terminally modified analogs of IL-8, GROα, and PF4 on CXCR1 and CXCR2
independently. Using stable Jurkat transfectants expressing either CXCR1 or CXCR2, it was …
(CXCR) 1 and CXCR2. IL-8 with changes to the NH 2-terminal ELR motif can block IL-8-
induced neutrophil functions (Moser, B., Dewald, B., Barella, L., Schumacher, C., Baggiolini,
M., and Clark-Lewis, I.(1993) J. Biol. Chem. 268, 7125–7128). We have now examined the
effect of NH 2-terminally modified analogs of IL-8, GROα, and PF4 on CXCR1 and CXCR2
independently. Using stable Jurkat transfectants expressing either CXCR1 or CXCR2, it was …