Elastase release from human alveolar macrophages: comparison between smokers and nonsmokers

RJ Rodriguez, RR White, RM Senior, EA Levine - Science, 1977 - science.org
RJ Rodriguez, RR White, RM Senior, EA Levine
Science, 1977science.org
Alveolar macrophages from smokers, in contrast to those of nonsmokers, release elastase
into serum-free culture medium. Since enzymes that digest elastin produce pulmonary
emphysema in experimental animals, release of elastase by alveolar macrophages from
smokers suggests that these cells are important in the pathogenesis of emphysema of
smokers.
Alveolar macrophages from smokers, in contrast to those of nonsmokers, release elastase into serum-free culture medium. Since enzymes that digest elastin produce pulmonary emphysema in experimental animals, release of elastase by alveolar macrophages from smokers suggests that these cells are important in the pathogenesis of emphysema of smokers.
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