EGFR enhances Survivin expression through the phosphoinositide 3 (PI-3) kinase signaling pathway
The ErbB family of receptor tyrosine kinases includes the epidermal growth factor receptor
(EGFR), p185/neu/c-erbB2, ErbB3, and ErbB4. Many of these receptors are overexpressed
or amplified in various forms of cancers. Previous studies have indicated that activation of
erbB molecules contributes to malignant transformation both by promoting cell proliferation
through the mitogen-activated protein kinase (MAP kinase) signaling pathway and by
preventing apoptosis through the Phosphoinositide 3 kinase (PI-3 kinase) pathway …
(EGFR), p185/neu/c-erbB2, ErbB3, and ErbB4. Many of these receptors are overexpressed
or amplified in various forms of cancers. Previous studies have indicated that activation of
erbB molecules contributes to malignant transformation both by promoting cell proliferation
through the mitogen-activated protein kinase (MAP kinase) signaling pathway and by
preventing apoptosis through the Phosphoinositide 3 kinase (PI-3 kinase) pathway …