[HTML][HTML] Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer
PL Depowski, SI Rosenthal, JS Ross - Modern Pathology, 2001 - Elsevier
Introduction: The PTEN gene, a candidate tumor suppressor, is localized to chromosome
10q23 and shares extensive homology with cytoskeletal proteins auxilin and tensin. A high
frequency of mutations at the PTEN locus has been described in a variety of neoplasms
including breast cancer. However, the role of PTEN alternations and its association with
outcome variables in breast neoplasia is not well established. Design: Formalin-fixed
paraffin embedded tissues from 151 women (mean age 62 years, range 26–98) with primary …
10q23 and shares extensive homology with cytoskeletal proteins auxilin and tensin. A high
frequency of mutations at the PTEN locus has been described in a variety of neoplasms
including breast cancer. However, the role of PTEN alternations and its association with
outcome variables in breast neoplasia is not well established. Design: Formalin-fixed
paraffin embedded tissues from 151 women (mean age 62 years, range 26–98) with primary …