[HTML][HTML] A copper-sensing transcription factor regulates iron uptake genes in Schizosaccharomyces pombe
S Labbé, MMO Pena, AR Fernandes… - Journal of Biological …, 1999 - ASBMB
Copper and iron serve essential functions as catalytic co-factors in a wide variety of critical
cellular enzymes. Studies in yeast have demonstrated an absolute dependence upon
copper acquisition for proper assembly and function of the iron transport machinery. We
have cloned genes for a high affinity copper transporter (Ctr4) and copper-sensing
transcription factor (Cuf1) fromSchizosaccharomyces pombe. Interestingly, the primary
structure of Ctr4 and a putative human high affinity copper transport protein, hCtr1, suggests …
cellular enzymes. Studies in yeast have demonstrated an absolute dependence upon
copper acquisition for proper assembly and function of the iron transport machinery. We
have cloned genes for a high affinity copper transporter (Ctr4) and copper-sensing
transcription factor (Cuf1) fromSchizosaccharomyces pombe. Interestingly, the primary
structure of Ctr4 and a putative human high affinity copper transport protein, hCtr1, suggests …