[HTML][HTML] Quantitative assessment of β1-and β2-adrenergic receptor homo-and heterodimerization by bioluminescence resonance energy transfer
JF Mercier, A Salahpour, S Angers, A Breit… - Journal of Biological …, 2002 - ASBMB
Quantitative bioluminescence resonance energy transfer (BRET) analysis was applied to the
study of β 1-and β 2-adrenergic receptor homo-and heterodimerization. To assess the
relative affinity between each of the protomers, BRET saturation experiments were carried
out in HEK-293T cells. β 1-and β 2-adrenergic receptors were found to have similar
propensity to engage in homo-and heterotropic interactions suggesting that, at equivalent
expression levels of the two receptor subtypes, an equal proportion of homo-and …
study of β 1-and β 2-adrenergic receptor homo-and heterodimerization. To assess the
relative affinity between each of the protomers, BRET saturation experiments were carried
out in HEK-293T cells. β 1-and β 2-adrenergic receptors were found to have similar
propensity to engage in homo-and heterotropic interactions suggesting that, at equivalent
expression levels of the two receptor subtypes, an equal proportion of homo-and …