[HTML][HTML] α-Synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen …
SV Kalivendi, S Cunningham, S Kotamraju… - Journal of Biological …, 2004 - ASBMB
1-Methyl-4-phenylpyridinium (MPP+) is a neurotoxin that causes Parkinson's disease in
experimental animals and humans. Despite the fact that intracellular iron was shown to be
crucial for MPP+-induced apoptotic cell death, the molecular mechanisms for the iron
requirement remain unclear. We investigated the role of transferrin receptor (TfR) and iron in
modulating the expression of α-synuclein (α-syn) in MPP+-induced oxidative stress and
apoptosis. Results show that MPP+ inhibits mitochondrial complex-1 and aconitase activities …
experimental animals and humans. Despite the fact that intracellular iron was shown to be
crucial for MPP+-induced apoptotic cell death, the molecular mechanisms for the iron
requirement remain unclear. We investigated the role of transferrin receptor (TfR) and iron in
modulating the expression of α-synuclein (α-syn) in MPP+-induced oxidative stress and
apoptosis. Results show that MPP+ inhibits mitochondrial complex-1 and aconitase activities …