[HTML][HTML] An Asn to Lys polymorphism in the third intracellular loop of the human α2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling

KM Small, SL Forbes, KM Brown, SB Liggett - Journal of Biological …, 2000 - ASBMB
α 2A-Adrenergic receptors (α 2A AR) are presynaptic autoinhibitory receptors of
noradrenergic neurons in the central and peripheral sympathetic nervous systems, which act
to dynamically regulate neurotransmitter release. Signaling through the G i/G o family of G-
proteins, the receptor subserves numerous homeostatic and central nervous system
functions. A single nucleotide polymorphism of this receptor, which results in an Asn to Lys
substitution at amino acid 251 of the third intracellular loop, was identified in the human …