Remarkable roles of proteolysis on and beyond the cell surface
CP Blobel - Current opinion in cell biology, 2000 - Elsevier
CP Blobel
Current opinion in cell biology, 2000•ElsevierProteolysis on the cell surface and in the extracellular matrix is essential for normal cellular
functions during development and in the adult, but it may also have undesirable
consequences, such as promoting cancer, arthritis, and Alzheimer's disease. Recent
advances highlight the roles of zinc-dependent metalloproteinases (metzincins) in proper
skeletal development, in activating EGF-receptor ligands, in Notch-dependent signaling, and
in initiating and promoting tumorigenesis.
functions during development and in the adult, but it may also have undesirable
consequences, such as promoting cancer, arthritis, and Alzheimer's disease. Recent
advances highlight the roles of zinc-dependent metalloproteinases (metzincins) in proper
skeletal development, in activating EGF-receptor ligands, in Notch-dependent signaling, and
in initiating and promoting tumorigenesis.
Proteolysis on the cell surface and in the extracellular matrix is essential for normal cellular functions during development and in the adult, but it may also have undesirable consequences, such as promoting cancer, arthritis, and Alzheimer’s disease. Recent advances highlight the roles of zinc-dependent metalloproteinases (metzincins) in proper skeletal development, in activating EGF-receptor ligands, in Notch-dependent signaling, and in initiating and promoting tumorigenesis.
Elsevier