A subset of macrophages located along the basement membrane (“lining cells”) is a characteristic histopathological feature of psoriasis
WH Boehncke, S Wortmann, R Kaufmann… - The American journal …, 1995 - journals.lww.com
In this paper, we describe the immunophenotype and ultrastructure of a new macrophage
subpopulation present in inflamed but not in normal human skin. In biopsy material from
patients with psoriasis (n= 4), atopic dermatitis (n= 4), and positive patch test reactions (n=
4), spindle-shaped macrophages located along the basement membrane were detected
staining positive for CDllc (LeuM5high, Ki-Ml low), CD68 (Ki-M6 low), and Ki-M8 (low). This
subpopulation was most prominent in psoriasis, where a median of 34 macrophages …
subpopulation present in inflamed but not in normal human skin. In biopsy material from
patients with psoriasis (n= 4), atopic dermatitis (n= 4), and positive patch test reactions (n=
4), spindle-shaped macrophages located along the basement membrane were detected
staining positive for CDllc (LeuM5high, Ki-Ml low), CD68 (Ki-M6 low), and Ki-M8 (low). This
subpopulation was most prominent in psoriasis, where a median of 34 macrophages …