Cytokine-secreting tumor cell vaccines
N Mach, G Dranoff - Current opinion in immunology, 2000 - Elsevier
N Mach, G Dranoff
Current opinion in immunology, 2000•ElsevierModification of the tumor microenvironment with gene transfer techniques stimulates two
immune mechanisms that effectuate tumor destruction. One involves improved tumor-
antigen presentation for the development of specific cellular and humoral immunity. The
second involves compromise of the tumor vasculature by soluble factors and leukocytes.
immune mechanisms that effectuate tumor destruction. One involves improved tumor-
antigen presentation for the development of specific cellular and humoral immunity. The
second involves compromise of the tumor vasculature by soluble factors and leukocytes.
Modification of the tumor microenvironment with gene transfer techniques stimulates two immune mechanisms that effectuate tumor destruction. One involves improved tumor-antigen presentation for the development of specific cellular and humoral immunity. The second involves compromise of the tumor vasculature by soluble factors and leukocytes.
Elsevier
