[HTML][HTML] Arachidonic acid in platelet microparticles up-regulates cyclooxygenase-2-dependent prostaglandin formation via a protein kinase C/mitogen-activated …
Activation of platelets results in shedding of membrane microparticles (MP) with potentially
bioactive properties. Platelet MP modulate platelet, monocyte, and vascular endothelial cell
function, both by direct effects of MP arachidonic acid (AA) and by its metabolism to bioactive
prostanoids. We have previously reported that platelet MP induce expression of
cyclooxygenase (COX)-2 and prostacyclin production in monocytes and endothelial cells. To
elucidate further the molecular mechanisms that underlie MP-induced up-regulation of COX …
bioactive properties. Platelet MP modulate platelet, monocyte, and vascular endothelial cell
function, both by direct effects of MP arachidonic acid (AA) and by its metabolism to bioactive
prostanoids. We have previously reported that platelet MP induce expression of
cyclooxygenase (COX)-2 and prostacyclin production in monocytes and endothelial cells. To
elucidate further the molecular mechanisms that underlie MP-induced up-regulation of COX …