[HTML][HTML] Transcriptional regulation of prostaglandin synthase 2 gene expression by platelet-derived growth factor and serum
W Xie, HR Herschman - Journal of Biological Chemistry, 1996 - ASBMB
Prostaglandin synthase 2 (PGS2) is an immediate-early gene induced in a variety of cellular
contexts. We investigate here the transcriptional activation of the murine PGS2 gene in NIH
3T3 cells, in response to the mitogens platelet-derived growth factor (PDGF) or serum. Site-
directed mutagenesis experiments demonstrate that a consensus cyclic AMP response
element (CRE) in the murine PGS2 promoter is essential for optimal PGS2 gene expression
in response to PDGF or to serum. Overexpression of c-Jun potentiates PDGF-or serum …
contexts. We investigate here the transcriptional activation of the murine PGS2 gene in NIH
3T3 cells, in response to the mitogens platelet-derived growth factor (PDGF) or serum. Site-
directed mutagenesis experiments demonstrate that a consensus cyclic AMP response
element (CRE) in the murine PGS2 promoter is essential for optimal PGS2 gene expression
in response to PDGF or to serum. Overexpression of c-Jun potentiates PDGF-or serum …