Signaling to translational control pathways: diversity in gene regulation in inflammatory and vascular cells
SW Lindemann, AS Weyrich, GA Zimmerman - Trends in cardiovascular …, 2005 - Elsevier
The expression of a subset of genes is strongly controlled at translational checkpoints, a
major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive
outside-in signals to specialized pathways that regulate translation of specific messenger
RNAs in a transcript-specific fashion and thereby influence key features of cellular
phenotype. These pathways and the expression of proteins that they control may be
dysregulated in cardiovascular diseases and are therapeutic targets.
major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive
outside-in signals to specialized pathways that regulate translation of specific messenger
RNAs in a transcript-specific fashion and thereby influence key features of cellular
phenotype. These pathways and the expression of proteins that they control may be
dysregulated in cardiovascular diseases and are therapeutic targets.