[HTML][HTML] A novel superoxide-producing NAD (P) H oxidase in kidney
A Shiose, J Kuroda, K Tsuruya, M Hirai… - Journal of Biological …, 2001 - ASBMB
During phagocytosis, gp91 phox, the catalytic subunit of the phagocyte NADPH oxidase,
becomes activated to produce superoxide, a precursor of microbicidal oxidants. Currently
increasing evidence suggests that nonphagocytic cells contain similar superoxide-
producing oxidases, which are proposed to play crucial roles in various events such as cell
proliferation and oxygen sensing for erythropoiesis. Here we describe the cloning of human
cDNA that encodes a novel NAD (P) H oxidase, designated NOX4. The NOX4 protein of 578 …
becomes activated to produce superoxide, a precursor of microbicidal oxidants. Currently
increasing evidence suggests that nonphagocytic cells contain similar superoxide-
producing oxidases, which are proposed to play crucial roles in various events such as cell
proliferation and oxygen sensing for erythropoiesis. Here we describe the cloning of human
cDNA that encodes a novel NAD (P) H oxidase, designated NOX4. The NOX4 protein of 578 …