[HTML][HTML] Interaction of the adenovirus 14.7-kDa protein with FLICE inhibits Fas ligand-induced apoptosis
P Chen, J Tian, I Kovesdi, JT Bruder - Journal of Biological Chemistry, 1998 - ASBMB
Adenovirus type 5 encodes a 14.7-kDa protein that protects infected cells from tumor
necrosis factor-induced cytolysis by an unknown mechanism. In this report, we demonstrate
that infection of cells with an adenovirus vector expressing Fas ligand induced rapid
apoptosis that was blocked by coinfection with a virus expressing 14.7 K. Moreover,
AdFasL/G infection resulted in the rapid activation of DEVD-specific caspases, and caspase
activation was blocked by coinfection with Ad14. 7/G. Cell death induced by the …
necrosis factor-induced cytolysis by an unknown mechanism. In this report, we demonstrate
that infection of cells with an adenovirus vector expressing Fas ligand induced rapid
apoptosis that was blocked by coinfection with a virus expressing 14.7 K. Moreover,
AdFasL/G infection resulted in the rapid activation of DEVD-specific caspases, and caspase
activation was blocked by coinfection with Ad14. 7/G. Cell death induced by the …