[HTML][HTML] Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor …
N Harper, M Hughes, M MacFarlane… - Journal of Biological …, 2003 - ASBMB
Death receptors are a subfamily of the tumor necrosis factor (TNF) receptor subfamily. They
are characterized by a death domain (DD) motif within their intracellular domain, which is
required for the induction of apoptosis. Fas-associated death domain protein (FADD) is
reported to be the universal adaptor used by death receptors to recruit and activate the
initiator caspase-8. CD95, TNF-related apoptosis-inducing ligand (TRAIL-R1), and TRAIL-
R2 bind FADD directly, whereas recruitment to TNF-R1 is indirect through another adaptor …
are characterized by a death domain (DD) motif within their intracellular domain, which is
required for the induction of apoptosis. Fas-associated death domain protein (FADD) is
reported to be the universal adaptor used by death receptors to recruit and activate the
initiator caspase-8. CD95, TNF-related apoptosis-inducing ligand (TRAIL-R1), and TRAIL-
R2 bind FADD directly, whereas recruitment to TNF-R1 is indirect through another adaptor …