[HTML][HTML] Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling
S Schutze, T Machleidt, D Adam, R Schwandner… - Journal of Biological …, 1999 - ASBMB
The 55-kDa receptor for tumor necrosis factor (TR55) triggers multiple signaling cascades
initiated by adapter proteins like TRADD and FAN. By use of the primary amine
monodansylcadaverine (MDC), we addressed the functional role of tumor necrosis factor
(TNF) receptor internalization for intracellular signal distribution. We show that MDC does
not prevent the interaction of the p55 TNF receptor (TR55) with FAN and TRADD.
Furthermore, the activation of plasmamembrane-associated neutral sphingomyelinase …
initiated by adapter proteins like TRADD and FAN. By use of the primary amine
monodansylcadaverine (MDC), we addressed the functional role of tumor necrosis factor
(TNF) receptor internalization for intracellular signal distribution. We show that MDC does
not prevent the interaction of the p55 TNF receptor (TR55) with FAN and TRADD.
Furthermore, the activation of plasmamembrane-associated neutral sphingomyelinase …