Genetic diversity of HLA-A2: evolutionary and functional significance

M Browning, P Krausa - Immunology today, 1996 - cell.com
M Browning, P Krausa
Immunology today, 1996cell.com
Rl'rnlf~ tlllli ('~! 1I1l1l's/wWII tllIIl'ljur hi~ IOCOI11P'llibi! il)'compkx (MilO cla~ s I molL'C\dc~,
1rt.: highly polymorphic cdl-~ urf, lc (, rli~ l,. ilJIIliVII mrit'~ IItnrkrdlll g< 1VC rise to ilmino
acid<; ub:. lilulions. Sc-colld, the miljorily of polynlOrphi... m within A'" 02 encodes amino ildd
sub:. titu· lion~ Ihill cluster around the peplide· binding groovC'of the! ILA· A2 mok'cu1c The
dala~ lIgge!> t Ih011 chang.:.'S ill the pep. tide· b111ding groove ibelf influence the<;
ek'Ction of new V, lTi, llll~, most prob, lbly throll~ h th" binding of pcptLdl.., th, llmedi" lc a …
Rl'rnlf~ tlllli ('~! 1I1l1l's/wWII tllIIl
'ljur hi~ IOCOI11P'llibi! il)'compkx (MilO cla~ s I molL'C\dc~, 1rt.: highly polymorphic cdl-~ urf, lc (, rli~ l,. ilJIIliVII mrit'~ IItnrkrdlll g< 1VC rise to ilmino acid<; ub:. lilulions. Sc-colld, the miljorily of polynlOrphi... m within A'" 02 encodes amino ildd sub:. titu· lion~ Ihill cluster around the peplide· binding groovC'of the! ILA· A2 mok'cu1c The dala~ lIgge!> t Ih011 chang.:.'S ill the pep. tide· b111ding groove ibelf influence the<; ek'Ction of new V, lTi, llll~, most prob, lbly throll~ h th" binding of pcptLdl.., th, llmedi" lc a pTIltl'Ctive immune rt:'ponsc 10 a potentially lethal pathogcn. Such a 1l1C" C11olni... nl h, l:'been pmposl> d to accounl ((lr the hi,(; h inci· denc... of HLA-1333 in Wl'St Afric. 11l popu, glycoprOlcllls th;)!, KI as antigcn-pn.-scnting 11Io1ccu1 ('S to. ltllig~· n-spccj (ic CDS T cell.. by d isplJyinS~ horl p~'ptidc fr'lgmenl~ de-TJvcd from IIltr, lcclllll, H protclll~ l. The 1110..\(Oml11 (> 11 hum., n MHC c1.,~~ I nlok'Culc I" IILA-A2, which is found ill high fn..-qucncy in most p<'pUI'ltion~!. This-. cro [Ogic, ll1y defined spo,.. dficily I~ Cllc (k. tcd by, 11 lea...[7 closely rl'i, ltL'l: l, llicle..(dc.. iglloltL'd A· V201-A'(117)'
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