Inhibition of coagulation and inflammation by activated protein C or antithrombin reduces intestinal ischemia/reperfusion injury in rats
IG Schoots, M Levi, AK van Vliet, AM Maas… - Critical care …, 2004 - journals.lww.com
Objective: To examine whether administration of activated protein C or antithrombin reduces
local splanchnic derangement of coagulation and inflammation and attenuates intestinal
dysfunction and injury following intestinal ischemia/reperfusion. Design: Randomized
prospective animal study. Setting: University research institute. Subjects: Adult male Wistar
rats, weighing 300–325 g (n= 72). Interventions: Rats were subjected to superior mesenteric
artery occlusion consisting of 20 or 40 mins of ischemia and 3 hrs of reperfusion. A …
local splanchnic derangement of coagulation and inflammation and attenuates intestinal
dysfunction and injury following intestinal ischemia/reperfusion. Design: Randomized
prospective animal study. Setting: University research institute. Subjects: Adult male Wistar
rats, weighing 300–325 g (n= 72). Interventions: Rats were subjected to superior mesenteric
artery occlusion consisting of 20 or 40 mins of ischemia and 3 hrs of reperfusion. A …
