[HTML][HTML] Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
DE Joyce, L Gelbert, A Ciaccia, B DeHoff… - Journal of Biological …, 2001 - ASBMB
Human protein C is a natural anticoagulant factor, and a recombinant activated form of the
molecule (rhAPC) is completing clinical evaluation for treatment of severe sepsis. Because
of the pathophysiologic role of endothelial dysfunction in severe inflammatory disease and
sepsis, we explored the possibility that rhAPC might directly modulate endothelial function,
independent of its anticoagulant activity. Using broad transcriptional profiling, we show that
rhAPC directly modulates patterns of endothelial cell gene expression clustering into anti …
molecule (rhAPC) is completing clinical evaluation for treatment of severe sepsis. Because
of the pathophysiologic role of endothelial dysfunction in severe inflammatory disease and
sepsis, we explored the possibility that rhAPC might directly modulate endothelial function,
independent of its anticoagulant activity. Using broad transcriptional profiling, we show that
rhAPC directly modulates patterns of endothelial cell gene expression clustering into anti …