[HTML][HTML] FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression: implications for PTEN mutation in prostate cancer
V Modur, R Nagarajan, BM Evers, J Milbrandt - Journal of Biological …, 2002 - ASBMB
Mutations in PTEN occur in 60–80% of prostate cancers and lead to a constitutive activation
of the phosphatidylinositol 3-kinase pathway and a resultant loss of activity of the FOXO
family of forkhead transcription factors FKHRL1 and FKHR. To provide insight into the role of
PTENmutations in prostate cancer, we used microarrays to identify genes regulated by
FKHRL1 and FKHR in LAPC4 prostate carcinoma cells. These studies revealed that
adenoviral overexpression of FKHRL1 and FKHR in the LAPC4 prostate cancer cell line …
of the phosphatidylinositol 3-kinase pathway and a resultant loss of activity of the FOXO
family of forkhead transcription factors FKHRL1 and FKHR. To provide insight into the role of
PTENmutations in prostate cancer, we used microarrays to identify genes regulated by
FKHRL1 and FKHR in LAPC4 prostate carcinoma cells. These studies revealed that
adenoviral overexpression of FKHRL1 and FKHR in the LAPC4 prostate cancer cell line …