[HTML][HTML] Effector and memory T-cell differentiation: implications for vaccine development

SM Kaech, EJ Wherry, R Ahmed - Nature Reviews Immunology, 2002 - nature.com
Nature Reviews Immunology, 2002nature.com
Recent work shows that after stimulation with antigen, CD4+ and CD8+ T cells embark on a
programme of proliferation that is closely linked with the acquisition of effector functions and
leads ultimately to memory-cell formation. Here, we discuss the signals required for
commitment to this programme of development and the factors that might influence its
progression. Models of the pathways of effector and memory T-cell differentiation are
discussed, and we highlight the implications of this new understanding for the optimization …
Abstract
Recent work shows that after stimulation with antigen, CD4+ and CD8+ T cells embark on a programme of proliferation that is closely linked with the acquisition of effector functions and leads ultimately to memory-cell formation. Here, we discuss the signals required for commitment to this programme of development and the factors that might influence its progression. Models of the pathways of effector and memory T-cell differentiation are discussed, and we highlight the implications of this new understanding for the optimization of vaccine strategies.
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