IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice
J Marks-Konczalik, S Dubois, JM Losi… - Proceedings of the …, 2000 - National Acad Sciences
J Marks-Konczalik, S Dubois, JM Losi, H Sabzevari, N Yamada, L Feigenbaum…
Proceedings of the National Academy of Sciences, 2000•National Acad SciencesA transgenic (Tg) mouse expressing human IL-15 was generated to define the role of IL-15
in the normal immune response. Overexpression of IL-15 resulted in an increase of NK,
CD44hiCD8 memory T cells, and γδ T cells. Additionally, we observed the emergence of a
novel type of NK-T cells with CD8αα′ expression. Due to the expansion and activation of
NK cells, the IL-15Tg mouse showed enhanced innate immunity. In adaptive T cell immunity,
the roles of IL-15 contrasted with those of IL-2. IL-15 inhibited IL-2-induced T cell death …
in the normal immune response. Overexpression of IL-15 resulted in an increase of NK,
CD44hiCD8 memory T cells, and γδ T cells. Additionally, we observed the emergence of a
novel type of NK-T cells with CD8αα′ expression. Due to the expansion and activation of
NK cells, the IL-15Tg mouse showed enhanced innate immunity. In adaptive T cell immunity,
the roles of IL-15 contrasted with those of IL-2. IL-15 inhibited IL-2-induced T cell death …
A transgenic (Tg) mouse expressing human IL-15 was generated to define the role of IL-15 in the normal immune response. Overexpression of IL-15 resulted in an increase of NK, CD44hiCD8 memory T cells, and γδ T cells. Additionally, we observed the emergence of a novel type of NK-T cells with CD8αα′ expression. Due to the expansion and activation of NK cells, the IL-15Tg mouse showed enhanced innate immunity. In adaptive T cell immunity, the roles of IL-15 contrasted with those of IL-2. IL-15 inhibited IL-2-induced T cell death, which plays a role in the maintenance of peripheral self-tolerance. IL-15 thus seems to contribute to enhanced immune memory by selectively propagating memory T cells and by blocking T cell death mediated by IL-2.
National Acad Sciences