Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity

SK Oh, JA Berzofsky, DS Burke… - Proceedings of the …, 2003 - National Acad Sciences
SK Oh, JA Berzofsky, DS Burke, TA Waldmann, LP Perera
Proceedings of the National Academy of Sciences, 2003National Acad Sciences
Vaccine efficacy is determined largely by cellular and humoral immunity as well as long-
lasting immunological memory. IL-2 and IL-15 were evaluated in vaccinia vectors
expressing HIV gp160 for the establishment of an effective vaccine strategy. Both IL-2 and IL-
15 in the vaccinia vector induced strong and long-lasting antibody-mediated immunity as
well as a short-term cytotoxic T cell response against HIV gp120. In addition, IL-15 also
supported robust CD8+ T cell-mediated long-term immunity, whereas the CD8+ T cell …
Vaccine efficacy is determined largely by cellular and humoral immunity as well as long-lasting immunological memory. IL-2 and IL-15 were evaluated in vaccinia vectors expressing HIV gp160 for the establishment of an effective vaccine strategy. Both IL-2 and IL-15 in the vaccinia vector induced strong and long-lasting antibody-mediated immunity as well as a short-term cytotoxic T cell response against HIV gp120. In addition, IL-15 also supported robust CD8+ T cell-mediated long-term immunity, whereas the CD8+ T cell-mediated immunity induced by IL-2 was short-lived. Moreover, we found that the cytokine milieu at the time of priming had surprisingly persistent effects on the character of the memory CD8 T cells long afterward with respect to their fate, functional activities, cytokine receptor expression, and antigen-independent proliferation.
National Acad Sciences