Angiotensin and bradykinin peptides in rats with myocardial infarction
AM Duncan, LM Burrell, A Kladis, DJ Campbell - Journal of cardiac failure, 1997 - Elsevier
Background: Angiotensin II (Ang II) stimulates cardiac hypertrophy and fibrosis, whereas
bradykinin [BK-(1–9)] has cardioprotective actions and reduces infarct size following
myocardial infarction. Methods and Results: We investigated whether myocardial infarction
and cardiac failure are associated with changes in circulating and tissue levels of
angiotensin and bradykinin peptides. Myocardial infarction was produced in rats by coronary
artery ligation and confirmed by electrocardiogram. Ang II, Ang I, BK-(1–9), and its …
bradykinin [BK-(1–9)] has cardioprotective actions and reduces infarct size following
myocardial infarction. Methods and Results: We investigated whether myocardial infarction
and cardiac failure are associated with changes in circulating and tissue levels of
angiotensin and bradykinin peptides. Myocardial infarction was produced in rats by coronary
artery ligation and confirmed by electrocardiogram. Ang II, Ang I, BK-(1–9), and its …