Latent transforming growth factor-β binding proteins (LTBPs)—structural extracellular matrix proteins for targeting TGF-β action
J Saharinen, M Hyytiäinen, J Taipale… - Cytokine & growth factor …, 1999 - Elsevier
Growth factors of the transforming growth factor-β family are potent regulators of the
extracellular matrix formation, in addition to their immunomodulatory and regulatory roles for
cell growth. TGF-βs are secreted from cells as latent complexes containing TGF-β and its
propeptide, LAP (latency-associated peptide). In most cells LAP is covalently linked to an
additional protein, latent TGF-β binding protein (LTBP), forming the large latent complex.
LTBPs are required for efficient secretion and correct folding of TGF-βs. The secreted large …
extracellular matrix formation, in addition to their immunomodulatory and regulatory roles for
cell growth. TGF-βs are secreted from cells as latent complexes containing TGF-β and its
propeptide, LAP (latency-associated peptide). In most cells LAP is covalently linked to an
additional protein, latent TGF-β binding protein (LTBP), forming the large latent complex.
LTBPs are required for efficient secretion and correct folding of TGF-βs. The secreted large …
