Structure and function of neuronal Ca2+ channels and their role in neurotransmitter release
WA Catterall - Cell calcium, 1998 - Elsevier
Electrophysiological studies of neurons reveal different Ca2+ currents designated L-, N-, P-,
Q-, R-, and T-type. High-voltage-activated neuronal Ca2+ channels are complexes of a pore-
forming al subunit of about 190–250 kDa, a transmembrane, disulfide-linked complex of α2
and δ subunits, and an intracellular β subunit, similar to the α1, α2δ, and β subunits
previously described for skeletal muscle Ca2+ channels. The primary structures of these
subunits have all been determined by homology cDNA cloning using the corresponding …
Q-, R-, and T-type. High-voltage-activated neuronal Ca2+ channels are complexes of a pore-
forming al subunit of about 190–250 kDa, a transmembrane, disulfide-linked complex of α2
and δ subunits, and an intracellular β subunit, similar to the α1, α2δ, and β subunits
previously described for skeletal muscle Ca2+ channels. The primary structures of these
subunits have all been determined by homology cDNA cloning using the corresponding …